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COLD START / catalog / c/profluentretrieved 2026-07-02T14:27 UTC · 17 sources read

Profluent

Profluent uses frontier AI models to design new proteins for therapeutics, agriculture, and biomanufacturing.

profluent.bio · Emeryville

CALL NO.CS·PROFLUENT·26
StageSeries BNovember 2025 · led by Bezos Expeditions[1][2][3][4][5][9]
Raised$150Mdisclosed rounds[2][3][4][9]
Headcount53as of May 2026[8]
Valuationnot publicly disclosedno source in ledger
Founded2022[8][7]
Money

Raised $150M across disclosed rounds.[2][3][4][9]

Series B closed November 2025, led by Bezos Expeditions.[1][2][3][4][5][9]

post-money valuation is not publicly disclosed.

Named investors include Insight Partners, Air Street Capital, AIX Ventures, Phoenix Venture Partners, Spark Capital, Bezos Expeditions, Altimeter Capital.[7][8][1][2][3][4][5][9]

People

Ali Madani, Founder and CEO[10][11][16]

Alexander Meeske, Co-Founder[10][11][16]

Hilary Eaton, Chief Business Officer[12][13][14][15][16]

Peter Cameron, SVP, Gene Editing and Translation[12][13][14][15][16]

Aaron Schwartz, General Manager, Emerging Technology[12][13][14][15][16]

Stephen Nayfach, Head of Bioinformatics and Platform R&D[12][13][14][15][16]

Signals
Jul 2 2026newsProfluent company claim, not independently confirmed[8]
Apr 28 2026launchProfluent announces strategic partnership with Eli Lilly to develop AI-designed recombinases for genetic medicine company claim, not independently confirmed[9]
Apr 28 2026newsLilly pens $2.2B gene editing pact with Bezos-backed Profluent[17]
Nov 19 2025fundingProfluent raises $106M Series B co-led by Bezos Expeditions and Altimeter Capital at nearly $1B valuation[1][2][3][4][5][6][9]
Apr 22 2024launchProfluent releases OpenCRISPR-1, the first AI-designed open-source gene editor company claim, not independently confirmed[9]
Mar 21 2024fundingProfluent raises $35M venture round led by Spark Capital company claim, not independently confirmed[8]
Comps

Isomorphic Labs · isomorphiclabs.com · Competes for AI biotech talent, pharma partnerships, and the thesis that AI models can design therapeutics; Isomorphic raised $600M in 2025.[1]

InSilico Medicine · insilico.com · Overlaps on AI-driven therapeutic design and pharma partnerships; raised $123M in 2025.[1]

Ginkgo Bioworks · ginkgobioworks.com · Overlaps on protein engineering services and agriculture partnerships; Profluent hired Ginkgo's former VP of BD.[14]

Investor Lens
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Filled in the side panel for invited readers. This card carries sourced facts only.

Sourcestracings · 17

Jul 2026 · finsmes.com

reported

Jul 2026 · bioxconomy.com

reported

Jul 2026 · profluent.bio

company

Jul 2026 · linkedin.com

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[16]GitHub

Jul 2026 · github.com

reported

Profluent

CALL NO.CS·PROFLUENT·26

Profluent uses frontier AI models to design new proteins for therapeutics, agriculture, and biomanufacturing.

profluent.bio · Emeryville

StageSeries B
Raised$150M
Headcount53
Valuationnot publicly disclosed
Founded2022
CompsIsomorphic Labs +2